Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia

Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia

Native amine dehydrogenases (nat-AmDHs) catalyze the (S)-stereoselective reductive amination of various ketones and aldehydes in the presence of high concentrations of ammonia. Based on the structure of CfusAmDH from Cystobacter fuscus complexed with Nicotinamide adenine dinucleotide phosphate (NADP...

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Bibliographic Details
Main Authors: Aurélie Fossey-Jouenne, Laurine Ducrot, Ewald P. J. Jongkind, Eddy Elisée, Anne Zaparucha, Gideon Grogan, Caroline E. Paul, Carine Vergne-Vaxelaire
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Catalysis
Subjects:
amine dehydrogenases
ketoreduction
reductive amination
alcohol
docking
Online Access:https://www.frontiersin.org/articles/10.3389/fctls.2023.1105948/full

Internet

https://www.frontiersin.org/articles/10.3389/fctls.2023.1105948/full

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