AAV-BDNF gene therapy ameliorates a hypothalamic neuroinflammatory signature in the Magel2-null model of Prader-Willi syndrome

AAV-BDNF gene therapy ameliorates a hypothalamic neuroinflammatory signature in the Magel2-null model of Prader-Willi syndrome

Individuals with Prader-Willi syndrome (PWS) exhibit several metabolic and behavioral abnormalities associated with excessive food-seeking activity. PWS is thought to be driven in part by dysfunctional hypothalamic circuitry and blunted responses to peripheral signals of satiety. Previous work descr...

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Bibliographic Details
Main Authors: Nicholas J. Queen, Wei Huang, Xunchang Zou, Xiaokui Mo, Lei Cao
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
adeno-associated virus
gene therapy
BDNF
brain-derived neurotrophic factor
Prader-Willi syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001419

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http://www.sciencedirect.com/science/article/pii/S2329050123001419

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