Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes [version 2; peer review: 2 approved]

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes [version 2; peer review: 2 approved]

Background Uveal melanoma is a poor prognosis cancer. Ergolide, a sesquiterpene lactone isolated from Inula Brittanica, exerts anti-cancer properties. The objective of this study was to 1) evaluate whether ergolide reduced metastatic uveal melanoma (MUM) cell survival/viability in vitro and in vivo;...

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Bibliographic Details
Main Authors: Husvinee Sundaramurthi, Kieran Wynne, Valentina Tonelotto, Eve O’Reilly, Fiona O'Connell, Csenger Kovácsházi, Marcel Costa-Garcia, Simone Marcone, Agnes Kittel, Eva Pallinger, Alfonso Blanco, Breandán N. Kennedy, Jose Maria Piulats Rodriguez, Szabolcs Hambalkó, Jacintha O'Sullivan, Péter Ferdinandy, Lasse D. Jensen, David Matallanas, Zoltán Giricz
Format: Article
Language:English
Published: F1000 Research Ltd 2023-11-01
Series:Open Research Europe
Subjects:
Metastatic uveal melanoma
ergolide
extracellular vesicles
BRCA2 and CDKN1A Interacting Protein
Chitinase Domain Containing 1
eng
Online Access:https://open-research-europe.ec.europa.eu/articles/3-88/v2

Internet

https://open-research-europe.ec.europa.eu/articles/3-88/v2

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