Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery of transgenes and potential risk of teratoma formation present challenges for in vivo appl...

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Bibliographic Details
Main Authors: Wayne Mitchell, Ludger JE Goeminne, Alexander Tyshkovskiy, Sirui Zhang, Julie Y Chen, Joao A Paulo, Kerry A Pierce, Angelina H Choy, Clary B Clish, Steven P Gygi, Vadim N Gladyshev
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
aging
reprogramming
mitochondria
oxidative phosphorylation
biological age
Online Access:https://elifesciences.org/articles/90579

Internet

https://elifesciences.org/articles/90579

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