Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

<p>Abstract</p> <p>Background</p> <p>Reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitive to oncolytic reovirus,...

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Bibliographic Details
Main Authors: Twigger Katie, Roulstone Victoria, Kyula Joan, Karapanagiotou Eleni M, Syrigos Konstantinos N, Morgan Richard, White Christine, Bhide Shreerang, Nuovo Gerard, Coffey Matt, Thompson Brad, Jebar Adel, Errington Fiona, Melcher Alan A, Vile Richard G, Pandha Hardev S, Harrington Kevin J
Format: Article
Language:English
Published: BMC 2012-08-01
Series:BMC Cancer
Subjects:
Biomarker
Cancer
EGFR
Ras
Reovirus
Oncolytic virus
Online Access:http://www.biomedcentral.com/1471-2407/12/368

Internet

http://www.biomedcentral.com/1471-2407/12/368

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