Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2014-07-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/increased-trypanosoma-brucei-cathepsin-l-activity-inhibits-human-serum-mediated-trypanolysis/ |
| _version_ | 1826532059852570624 |
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| author | Sam Alsford |
| author_facet | Sam Alsford |
| author_sort | Sam Alsford |
| collection | DOAJ |
| description | Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action. |
| first_indexed | 2024-12-20T04:18:57Z |
| format | Article |
| id | doaj.art-c3416d940fb547d18e700fe34b58996c |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2025-03-14T01:45:13Z |
| publishDate | 2014-07-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-c3416d940fb547d18e700fe34b58996c2025-03-12T13:46:41ZengShared Science Publishers OGMicrobial Cell2311-26382014-07-011827027210.15698/mic2014.08.162Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysisSam Alsford0London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action.http://microbialcell.com/researcharticles/increased-trypanosoma-brucei-cathepsin-l-activity-inhibits-human-serum-mediated-trypanolysis/Trypanosoma bruceitrypanolysiscathepsin-Linnate immunitylysosome |
| spellingShingle | Sam Alsford Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis Microbial Cell Trypanosoma brucei trypanolysis cathepsin-L innate immunity lysosome |
| title | Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis |
| title_full | Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis |
| title_fullStr | Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis |
| title_full_unstemmed | Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis |
| title_short | Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis |
| title_sort | increased trypanosoma brucei cathepsin l activity inhibits human serum mediated trypanolysis |
| topic | Trypanosoma brucei trypanolysis cathepsin-L innate immunity lysosome |
| url | http://microbialcell.com/researcharticles/increased-trypanosoma-brucei-cathepsin-l-activity-inhibits-human-serum-mediated-trypanolysis/ |
| work_keys_str_mv | AT samalsford increasedtrypanosomabruceicathepsinlactivityinhibitshumanserummediatedtrypanolysis |