神经调节素1β通过激活Sirt1信号通路抑制自噬改善大鼠脑缺血再灌注损伤研究 Neuregulin 1β Improves Cerebral Ischemia Reperfusion Injury by Inhibiting Autophagy via Sirt1 Signaling Pathway in Rats
目的 探讨神经调节素1β(neuregulin 1β,NRG1β)是否通过抑制自噬减轻大鼠大脑中动脉缺血再灌注(middle cerebral artery occlusion reperfusion,MCAO/R)损伤,以及对沉默信息调节因子1(silent information regulator protein 1,Sirt1)信号通路的影响。 方法 将210只健康雄性SD大鼠随机分为假手术组(Sham组)、模型组(MCAO/R组)、治疗组(NRG1β组)、激动剂组(SRT501组)、激动剂+治疗组(SRT501+NRG1β组)、抑制剂组(EX527组)和抑制剂+治疗组(EX527+...
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Format: | Article |
Language: | zho |
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Editorial Department of Chinese Journal of Stroke
2023-03-01
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Series: | Zhongguo cuzhong zazhi |
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Online Access: | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=3764 |