Impact of proton pump inhibitors on the onset of gastrointestinal immune‐related adverse events during immunotherapy

Impact of proton pump inhibitors on the onset of gastrointestinal immune‐related adverse events during immunotherapy

Abstract Introduction The gut microbiota (GM) can influence the pathogenesis of immune‐mediated adverse events (irAEs). Proton pump inhibitors (PPIs) can affect the integrity of GM, but their role in promoting irAEs is still poorly understood. Methods In this retrospective single‐center cohort study...

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Bibliographic Details
Main Authors: Angioletta Lasagna, Federica Mascaro, Simone Figini, Sara Basile, Giulia Gambini, Catherine Klersy, Marco Vincenzo Lenti, Antonio Di Sabatino, Alice Di Benedetto, Monica Calvi, Raffaele Bruno, Paolo Sacchi, Paolo Pedrazzoli
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Cancer Medicine
Subjects:
colitis
hepatitis
immune checkpoint inhibitors
microbiome
proton pomp inhibitors
toxicity
Online Access:https://doi.org/10.1002/cam4.6565

Internet

https://doi.org/10.1002/cam4.6565

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