Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Fibroblast growth factor receptors (FGFRs), a subfamily of receptor tyrosine kinases, are aberrant in various cancer types, and considered to be promising targets for cancer therapy. We started with a weak-active compound that was identified from our internal hepatocyte growth factor receptor (also...

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Bibliographic Details
Main Authors: Alan Jiang, Qiufeng Liu, Ruifeng Wang, Peng Wei, Yang Dai, Xin Wang, Yechun Xu, Yuchi Ma, Jing Ai, Jingkang Shen, Jian Ding, Bing Xiong
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
cancer
FGFR
kinase inhibitor
pyrrolo[2,3-b]pyrazine
Online Access:http://www.mdpi.com/1420-3049/23/3/698

Internet

http://www.mdpi.com/1420-3049/23/3/698

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