Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells

Summary: Mouse embryonic stem cells (ESCs) grown in serum-supplemented conditions are characterized by an extremely short G1 phase due to the lack of G1-phase control. Concordantly, the G1-phase-specific P53-P21 pathway is compromised in serum ESCs. Here, we provide evidence that P53 is activated up...

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Bibliographic Details
Main Authors: Menno ter Huurne, Tianran Peng, Guoqiang Yi, Guido van Mierlo, Hendrik Marks, Hendrik G. Stunnenberg
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671120300011