Amelioration of olfactory dysfunction in a mouse model of Parkinson’s disease via enhancing GABAergic signaling

Amelioration of olfactory dysfunction in a mouse model of Parkinson’s disease via enhancing GABAergic signaling

Abstract Background Olfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease (PD). As the foremost pathological hallmark, α-synuclein initiates the pathology in the olfactory pathway at the early stage of PD, particularly in the olfactory epithelium (OE) and olfactory bu...

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Main Authors: Xing-Yang Liu, Ke Wang, Xian-Hua Deng, Yi-Hua Wei, Rui Guo, Sui-Feng Liu, Yi-Fan Zhu, Jia-Jun Zhong, Jing-Yuan Zheng, Meng-Dan Wang, Qiu-Hong Ye, Jian-Quan He, Kai-Hang Guo, Jun-Rong Zhu, Shu-Qiong Huang, Ze-Xu Chen, Chong-Shan Lv, Lei Wen
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell & Bioscience
Subjects:
Parkinson’s disease
Olfactory dysfunction
GABAergic signaling
Excitation/inhibition imbalance
Online Access:https://doi.org/10.1186/s13578-023-01049-9

Internet

https://doi.org/10.1186/s13578-023-01049-9

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