Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study

Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study

<p>Abstract</p> <p>Background</p> <p>The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer.</p&g...

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Bibliographic Details
Main Authors: Kunos Charles, Radivoyevitch Tomas, Abdul-Karim Fadi W, Fanning James, Abulafia Ovadia, Bonebrake Albert J, Usha Lydia
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer
Ribonucleotide reductase
Triapine
Methemoglobinemia
Online Access:http://www.translational-medicine.com/content/10/1/79

Internet

http://www.translational-medicine.com/content/10/1/79

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