Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics

Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics

Abstract Background Patients with spondyloarthritis (SpA)/HLA-B27-associated acute anterior uveitis (AAU) experience recurring acute flares, which pose significant visual and financial challenges. Despite established links between SpA and HLA-B27-associated AAU, the exact mechanism involved remains...

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Bibliographic Details
Main Authors: Shuming Chen, Weidi Huang, Qiaoqian Wan, Zichun Tang, Xie Li, Fang Zeng, Shuyan Zheng, Zhuo Li, Xiao Liu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Translational Medicine
Subjects:
Anterior uveitis
Genetics
Mendelian randomization
Single-cell transcriptome
Online Access:https://doi.org/10.1186/s12967-024-05077-y

Internet

https://doi.org/10.1186/s12967-024-05077-y

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