Unusual phylogenetic tree and circulating actionable ESR1 mutations in an aggressive luminal/HER2-low breast cancer: Case report

Unusual phylogenetic tree and circulating actionable ESR1 mutations in an aggressive luminal/HER2-low breast cancer: Case report

Under therapeutic pressure aggressive tumors evolve rapidly. Herein, a luminal B/HER2-low breast cancer was tracked for >3 years during a total of 6 largely unsuccessful therapy lines, from adjuvant to advanced settings. Targeted next generation sequencing (NGS) of the primary lesion, two met...

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Bibliographic Details
Main Authors: Matteo Allegretti, Vittoria Barberi, Cristiana Ercolani, Antonello Vidiri, Elena Giordani, Gennaro Ciliberto, Patrizio Giacomini, Alessandra Fabi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
breast cancer
cancer evolution
liquid biopsy
ESR1
HER2
molecular tumor board
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1050452/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1050452/full

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