Construction of Windows for Pharmacokinetic Sampling
This paper describes a method for the construction of pharmacokinetic sampling windows so that they are around the $D$-optimum time points. Here we consider the situation where a pharmacokinetic (PK) study is accompanied by a dose-finding study in phase I clinical trial. The D-optimal criterion is o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Austrian Statistical Society
2021-08-01
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| Series: | Austrian Journal of Statistics |
| Online Access: | https://www.ajs.or.at/index.php/ajs/article/view/1110 |