The Contribution of HCN Channelopathies in Different Epileptic Syndromes, Mechanisms, Modulators, and Potential Treatment Targets: A Systematic Review

The Contribution of HCN Channelopathies in Different Epileptic Syndromes, Mechanisms, Modulators, and Potential Treatment Targets: A Systematic Review

BackgroundHyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA-mediated postsynaptic potentials, thereby suppressing epilepsy. However, it is unclear whether increased HCN current can produce e...

Full description

Bibliographic Details
Main Authors: Miriam Kessi, Jing Peng, Haolin Duan, Hailan He, Baiyu Chen, Juan Xiong, Ying Wang, Lifen Yang, Guoli Wang, Karlmax Kiprotich, Olumuyiwa A. Bamgbade, Fang He, Fei Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
HCN channelopathies
epilepsy
acquired channelopathy
neuro-inflammation
SUDEP
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.807202/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.807202/full

Similar Items