Antenatal Hypoxia and Programming of Glucocorticoid Receptor Expression in the Adult Rat Heart

Antenatal Hypoxia and Programming of Glucocorticoid Receptor Expression in the Adult Rat Heart

Glucocorticoid receptor (GR) signaling is critical for development and function of the heart. Our previous study demonstrated that gestational hypoxia induced epigenetic repression of the GR gene in the developing heart. The present study aims to determine that the alterations of promoter methylatio...

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Bibliographic Details
Main Authors: Juanxiu Lv, Qingyi Ma, Chiranjib Dasgupta, Zhice Xu, Lubo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
hypoxia
glucocorticoid receptor
programming
heart
DNA methylation
sex
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00323/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00323/full

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