Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease

Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease

Summary: Many clinical studies indicate a significant decrease of peripheral T cells in Parkinson’s disease (PD). There is currently no mechanistic explanation for this important observation. Here, we found that small extracellular vesicles (sEVs) derived from in vitro and in vivo PD models suppress...

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Bibliographic Details
Main Authors: Zhichun Chen, Wenming Li, Bo Meng, Chongchong Xu, Yiqi Huang, Guanglu Li, Zhexing Wen, Jun Liu, Zixu Mao
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Neuroscience
Systems neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224014688

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224014688

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