Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants.

Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants.

Show other versions (1)

We recently published a preliminary assessment of the activity of a poly (ADP-ribose) polymerase (PARP) inhibitor, stenoparib, also known as 2X-121, which inhibits viral replication by affecting pathways of the host. Here we show that stenoparib effectively inhibits a SARS-CoV-2 wild type (BavPat1/2...

Full description

Bibliographic Details
Main Authors: Katherine E Zarn, Sierra A Jaramillo, Anthony R Zapata, Nathan E Stone, Ashley N Jones, Haley E Nunnally, Erik W Settles, Ken Ng, Paul S Keim, Steen Knudsen, Patricia M Nuijten, Aloys S L Tijsma, Christopher T French
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0272916

Internet

https://doi.org/10.1371/journal.pone.0272916

Similar Items