Generation of dimeric single-chain antibodies neutralizing the cytolytic activity of vaginolysin

Generation of dimeric single-chain antibodies neutralizing the cytolytic activity of vaginolysin

Background: Gardnerella vaginalis is a bacterial vaginosis (BV)-associated vaginal bacterium that produces the toxin vaginolysin (VLY). VLY is a pore-forming toxin that is suggested to be the main virulence factor of G. vaginalis. The high recurrence rate of BV and the emergence of antibiotic-resist...

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Bibliographic Details
Main Authors: Zilvinas Dapkunas, Aurimas Baranauskas, Gitana Mickiene, Milda Pleckaityte, Gintautas Zvirblis
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Electronic Journal of Biotechnology
Subjects:
Circulation half-life
ELISA
Gardnerella vaginalis
Genetic fusion
Hemolysis
Medical biotechnology
Pore-forming toxin
Recombinant antibodies
Therapeutic agent
Vaginal bacterium
Virulence factor
Online Access:http://www.sciencedirect.com/science/article/pii/S0717345817300258

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http://www.sciencedirect.com/science/article/pii/S0717345817300258

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