Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities

Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities

ABSTRACT HIV reservoirs persist despite successful antiretroviral therapy (ART) and are a major obstacle to the eradication and cure of HIV. The mature monocyte subset, CD14+CD16+, contributes to viral reservoirs and HIV-associated comorbidities. Only a subset of monocytes harbors HIV (HIV+), while...

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Bibliographic Details
Main Authors: Rosiris León-Rivera, Brenda Morsey, Meng Niu, Howard S. Fox, Joan W. Berman
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
HIV
reservoirs
latency
transcriptome
HIV-associated comorbidities
Online Access:https://journals.asm.org/doi/10.1128/mBio.01037-20

Internet

https://journals.asm.org/doi/10.1128/mBio.01037-20

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