GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17

GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and it is thus critical to identify novel molecular biomarkers of HCC prognosis and elucidate the molecular mechanisms underlying HCC progression. Here, we show that G-protein-coupled receptor 50 (GPR50) in HCC is o...

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Bibliographic Details
Main Authors: Subbroto Kumar Saha, Hye Yeon Choi, Gwang-Mo Yang, Polash Kumar Biswas, Kyeongseok Kim, Geun-Ho Kang, Minchan Gil, Ssang-Goo Cho
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
GPR50
ADAM17
ligand-independent Notch signaling
hepatocellular carcinoma
HCC progression
HCC prognosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300528

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http://www.sciencedirect.com/science/article/pii/S2372770520300528

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