Use of Simvastatin, Fibrin Clots, and Their Combination to Improve Human Ovarian Tissue Grafting for Fertility Restoration After Anti-Cancer Therapy

Use of Simvastatin, Fibrin Clots, and Their Combination to Improve Human Ovarian Tissue Grafting for Fertility Restoration After Anti-Cancer Therapy

Anticancer treatments, particularly chemotherapy, induce ovarian damage and loss of ovarian follicles. There are limited options for fertility restoration, one of which is pre-chemotherapy cryopreservation of ovarian tissue. Transplantation of frozen-thawed human ovarian tissue from cancer survivors...

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Bibliographic Details
Main Authors: Roei Magen, Yoel Shufaro, Yair Daykan, Galia Oron, Elena Tararashkina, Shulamit Levenberg, Eli Anuka, Avi Ben-Haroush, Benjamin Fisch, Ronit Abir
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
transplantation
human ovarian tissue
immunodeficient mice
simvastatin
fibrin clots
mouse platelet endothelial cell adhesion molecule
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.598026/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.598026/full

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