Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice

Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice

Abstract Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinases, especially of Ret and the FGF receptors. As such, they play distinct and overlapping roles in embryo morphogenesis and are considered to be tumor suppressors in adult life. Genetic experiments in mic...

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Bibliographic Details
Main Authors: Gisela Altés, Anna Olomí, Aida Perramon-Güell, Sara Hernández, Anna Casanovas, Aurora Pérez, Juan Miguel Díaz-Tocados, José Manuel Valdivielso, Cristina Megino, Raúl Navaridas, Xavier Matias-Guiu, Ophir D. Klein, Joaquim Egea, Xavi Dolcet, Andrée Yeramian, Mario Encinas
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-70529-w

Internet

https://doi.org/10.1038/s41598-024-70529-w

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