PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

Hypoxia is typically the leading cause of radiotherapy (RT) resistance in solid tumors, and glutathione (GSH) overexpression in tumor cells is a potent antioxidant mechanism that protects tumor cells from radiation damage. Herein, we developed a sorafenib (SFN) loaded-PLGA hydrogel system (SPH) in c...

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Bibliographic Details
Main Authors: Ziqi Wang, Bo Liu, Jingyao Tu, Jingfeng Xiang, Hui Xiong, Yue Wu, Shuaijie Ding, Daoming Zhu, Dongyong Zhu, Fei Liu, Guangyuan Hu, Xianglin Yuan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
sorafenib
PLGA nanoparticles
microwave hyperthermia
radiotherapy
breast cancer
Online Access:https://www.mdpi.com/1999-4923/15/2/487

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https://www.mdpi.com/1999-4923/15/2/487

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