Nilotinib Enhances the Efficacy of Conventional Chemotherapeutic Drugs in CD34+CD38− Stem Cells and ABC Transporter Overexpressing Leukemia Cells

Nilotinib Enhances the Efficacy of Conventional Chemotherapeutic Drugs in CD34+CD38− Stem Cells and ABC Transporter Overexpressing Leukemia Cells

Incomplete chemotherapeutic eradication of leukemic CD34+CD38− stem cells is likely to result in disease relapse. The purpose of this study was to evaluate the effect of nilotinib on eradicating leukemia stem cells and enhancing the efficacy of chemotherapeutic agents. Our results showed that ABCB1...

Full description

Bibliographic Details
Main Authors: Fang Wang, Xiao-Kun Wang, Cheng-Jun Shi, Hui Zhang, Ya-Peng Hu, Yi-Fan Chen, Li-Wu Fu
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Molecules
Subjects:
nilotinib
leukemia stem cells
multidrug resistance
ATP-binding cassette transporters
ABCG2
ABCB1
Online Access:http://www.mdpi.com/1420-3049/19/3/3356

Internet

http://www.mdpi.com/1420-3049/19/3/3356

Similar Items