The Role of Conformational Dynamics and Allostery in the Control of Distinct Efficacies of Agonists to the Glucocorticoid Receptor

The Role of Conformational Dynamics and Allostery in the Control of Distinct Efficacies of Agonists to the Glucocorticoid Receptor

Glucocorticoid receptor (GR) regulates various cellular functions. Given its broad influence on metabolic activities, it has been the target of drug discovery for decades. However, how drugs induce conformational changes in GR has remained elusive. Herein, we used five GR agonists (dex, AZ938, pred,...

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Bibliographic Details
Main Authors: Yuxin Shi, Shu Cao, Duan Ni, Jigang Fan, Shaoyong Lu, Mintao Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
glucocorticoid receptor
allosteric communication
allosteric site
molecular dynamics simulation
drug discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.933676/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.933676/full

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