Dynamic evolution of ceftazidime–avibactam resistance due to interchanges between blaKPC-2 and blaKPC-145 during treatment of Klebsiella pneumoniae infection

Dynamic evolution of ceftazidime–avibactam resistance due to interchanges between blaKPC-2 and blaKPC-145 during treatment of Klebsiella pneumoniae infection

BackgroundThe emergence of ceftazidime–avibactam (CZA) resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) is of major concern due to limited therapeutic options.MethodsIn this study, 10 CRKP strains were isolated from different samples of a patient with CRKP infection receiving CZA t...

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Bibliographic Details
Main Authors: Yili Chen, Runshi Yang, Penghao Guo, Pingjuan Liu, Jiankai Deng, Zhongwen Wu, Qingping Wu, Junqi Huang, Kang Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
carbapenem resistance
Klebsiella pneumoniae
ceftazidime-avibactam resistance
KPC-2
KPC-145
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1244511/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1244511/full

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