A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death and electroretinogram distortion in a rat model of intraorbital optic nerve crush (IONC)

A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death and electroretinogram distortion in a rat model of intraorbital optic nerve crush (IONC)

Introduction: Ocular and periocular traumatisms may result in loss of vision. Our previous work showed that therapeutic hypothermia prevents retinal damage caused by traumatic neuropathy. We also generated and characterized small molecules that elicit the beneficial effects of hypothermia at normal...

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Bibliographic Details
Main Authors: Daniela S. Contartese, Manuel Rey-Funes, Rafael Peláez, Manuel Soliño, Juan C. Fernández, Ronan Nakamura, Nicolás S. Ciranna, Aníbal Sarotto, Verónica B. Dorfman, Juan J. López-Costa, José M. Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Ignacio M. Larrayoz, César F. Loidl, Alfredo Martínez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
traumatic optic neuropathy
therapeutic hypothermia
hypothermia mimetics
intravitreal injection
electroretinogram
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1112318/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1112318/full

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