A novel LRP1-binding peptide L57 that crosses the blood brain barrier

A novel LRP1-binding peptide L57 that crosses the blood brain barrier

The blood-brain barrier (BBB) is a major obstacle to drug delivery into the central nervous system (CNS), in particular for macromolecules such as peptides and proteins. However, certain macromolecules can reach the CNS via a receptor-mediated transcytosis (RMT) pathway, and low-density lipoprotein...

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Bibliographic Details
Main Authors: Kotaro Sakamoto, Tokuyuki Shinohara, Yusuke Adachi, Taiji Asami, Tetsuya Ohtaki
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Blood brain barrier
Low-density lipoprotein receptor-related protein 1
Peptide
Phage display
Receptor-mediated transcytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S240558081730081X

Internet

http://www.sciencedirect.com/science/article/pii/S240558081730081X

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