Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery

Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery

In colorectal cancer (CRC), KRAS mutations are a strong negative predictor for treatment with the EGFR‐targeted antibodies cetuximab and panitumumab. Since it can be difficult to obtain appropriate tumor tissues for KRAS genotyping, alternative methods are required. Circulating tumor cells (CTCs) ar...

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Bibliographic Details
Main Authors: Jérôme Alexandre Denis, Alexia Patroni, Erell Guillerm, Dominique Pépin, Naoual Benali-Furet, Janine Wechsler, Gilles Manceau, Maguy Bernard, Florence Coulet, Annette K. Larsen, Mehdi Karoui, Jean-Marc Lacorte
Format: Article
Language:English
Published: Wiley 2016-10-01
Series:Molecular Oncology
Subjects:
Digital PCR
KRAS
Circulating tumor cells
Colorectal cancer
Liquid biopsy
Online Access:https://doi.org/10.1016/j.molonc.2016.05.009

Internet

https://doi.org/10.1016/j.molonc.2016.05.009

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