In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity

In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity

Pain is one of the most common symptoms experienced by patients. The use of current analgesics is limited by low efficacy and important side effects. Transient receptor potential vanilloid-1 (TRPV1) is a non-selective cation channel, activated by capsaicin, heat, low pH or pro-inflammatory agents. S...

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Bibliographic Details
Main Authors: Corina Andrei, Dragos Paul Mihai, Anca Zanfirescu, George Mihai Nitulescu, Simona Negres
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
molecular docking
machine learning
pain
drug discovery
TRPV1 agonist
TRPV1 antagonist
Online Access:https://www.mdpi.com/1999-4923/14/12/2563

Internet

https://www.mdpi.com/1999-4923/14/12/2563

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