HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA

HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA

Unspliced, genomic HIV-1 RNA (vRNA) is a component of several ribonucleoprotein complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the host upframeshift protein 1 (UPF1), a key factor in nonsense-mediated mRNA decay (NMD), colocalized and associated to the vira...

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Bibliographic Details
Main Authors: Lara Ajamian, Karen Abel, Shringar Rao, Kishanda Vyboh, Francisco García-de-Gracia, Ricardo Soto-Rifo, Andreas E. Kulozik, Niels H. Gehring, Andrew J. Mouland
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Biomolecules
Subjects:
HIV-1
UPF1
ribonucleoprotein
nuclear RNA export
viral evasion
nonsense mediated decay
Online Access:http://www.mdpi.com/2218-273X/5/4/2808

Internet

http://www.mdpi.com/2218-273X/5/4/2808

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