5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction

5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction

The neuroprotective role of 5-hydroxymethyl-2-furfural (5-HMF) has been demonstrated in a variety of neurological diseases. The aim of this study is to investigate the effect of 5-HMF on multiple sclerosis (MS). IFN-γ-stimulated murine microglia (BV2 cells) are considered a cell model of MS. With 5-...

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Bibliographic Details
Main Authors: Guan Dongsheng, Li Yingxia, Cui Yinglin, Zhao Huanghong, Dong Ning, Wang Kun, Ren Deqi, Song Tiantian, Wang Xiaojing, Jin Shijie, Gao Yinghe, Wang Mengmeng
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-07-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
multiple sclerosis
experimental autoimmune encephalomyelitis
5-hydroxymethyl-2-furfural
M2 polarization
inflammation
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023105

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023105

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