Elucidating the Hot Spot Residues of Quorum Sensing Peptidic Autoinducer PapR by Multiple Amino Acid Replacements

Elucidating the Hot Spot Residues of Quorum Sensing Peptidic Autoinducer PapR by Multiple Amino Acid Replacements

The quorum sensing (QS) system of Bacillus cereus, an opportunistic human pathogen, utilizes the autoinducing PapR peptide signal that mediates the activation of the pleiotropic virulence regulator PlcR. A set of synthetic 7-mer PapR-derived peptides (PapR7; ADLPFEF) have been shown to inhibit effic...

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Bibliographic Details
Main Authors: Avishag Yehuda, Leyla Slamti, Einav Malach, Didier Lereclus, Zvi Hayouka
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Microbiology
Subjects:
quorum sensing
quorum quenching
PlcR antagonists
B. cereus group
anti-virulence peptides
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01246/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01246/full

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