The Structural Determinants for α<sub>1</sub>-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives

The Structural Determinants for α<sub>1</sub>-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives

Several studies confirmed the reciprocal interactions between adrenergic and serotoninergic systems and the influence of these phenomena on the pathogenesis of anxiety. Hence, searching for chemical agents with a multifunctional pharmacodynamic profile may bring highly effective therapy for CNS diso...

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Bibliographic Details
Main Authors: Katarzyna Kucwaj-Brysz, Anna Dela, Sabina Podlewska, Marek Bednarski, Agata Siwek, Grzegorz Satała, Kinga Czarnota, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
adrenergic receptors
serotonin receptors
G protein-coupled receptors
selectivity
docking
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/26/22/7025

Internet

https://www.mdpi.com/1420-3049/26/22/7025

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