Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome

Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome

Abstract Background Insulin resistance (IR) contributes to ovarian dysfunctions in polycystic ovarian syndrome (PCOS) patients. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver in response to inflammation. In addition to its role in inflammation, SAA1 may participate...

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Main Authors: Qinling Zhu, Yue Yao, Lizhen Xu, Hasiximuke Wu, Wangsheng Wang, Yaqiong He, Yuan Wang, Yao Lu, Jia Qi, Ying Ding, Xinyu Li, Jiaan Huang, Hanting Zhao, Yanzhi Du, Kang Sun, Yun Sun
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Reproductive Biology and Endocrinology
Subjects:
Serum amyloid A1
Polycystic ovary syndrome
Insulin resistance
Granulosa cells
Inflammation
Online Access:https://doi.org/10.1186/s12958-021-00873-3

Internet

https://doi.org/10.1186/s12958-021-00873-3

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