Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model

Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model

Lipid nanoparticles are promising carriers for oral drug delivery. For bioactive cargos with intracellular targets, e.g. gene-editing proteins, it is essential for the cargo and carrier to remain complexed after crossing the epithelial layer of intestine in order for the delivery system to transport...

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Bibliographic Details
Main Authors: Tao Yang, Haobo Han, Ying Chen, Liu Yang, Rachael Parker, Yamin Li, David L. Kaplan, Qiaobing Xu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-11-01
Series:Bioactive Materials
Subjects:
Lipidoid nanoparticle
Protein delivery
Oral drug delivery
Genome engineering
3D tissue model
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21001390

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http://www.sciencedirect.com/science/article/pii/S2452199X21001390

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