G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression

G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression

Cheng, Fan, Li et al. identified ANGPTL4 as a G1-induced target gene of GPER/YAP in HRT8 cells using RNA-seq and highlighted its importance in regulating trophoblast cell invasion. The authors also reported GPER downregulation in the placenta and lower estradiol levels in patients who developed pree...

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Bibliographic Details
Main Authors: Jung-Chien Cheng, Lanlan Fang, Yuxi Li, Avinash Thakur, Pamela A. Hoodless, Yanjie Guo, Zhen Wang, Ze Wu, Yang Yan, Qiongqiong Jia, Yibo Gao, Xiaoyu Han, Yiping Yu, Ying-Pu Sun
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02816-5

Internet

https://doi.org/10.1038/s42003-021-02816-5

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