Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling

Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling

Sphingosine kinase 1 (SPHK1) and the sphingosine-1-phosphate (S1P) signaling pathway have been shown to play a role in pulmonary arterial hypertension (PAH). S1P is an important stimulus for pulmonary artery smooth muscle cell (PASMC) proliferation and pulmonary vascular remodeling. We aimed to exam...

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Bibliographic Details
Main Authors: Jiwang Chen, Angelia Lockett, Shuangping Zhao, Long Shuang Huang, Yifan Wang, Weiwen Wu, Ming Tang, Shahzaib Haider, Daniela Velez Rendon, Raheel Khan, Bing Liu, Nicholas Felesena, Justin R. Sysol, Daniela Valdez-Jasso, Haiyang Tang, Yang Bai, Viswanathan Natarajan, Roberto F. Machado
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine kinase 1
S1P
pulmonary artery smooth muscle cell
proliferation
YAP1
verteporfin
Online Access:https://www.mdpi.com/1422-0067/23/23/14516

Internet

https://www.mdpi.com/1422-0067/23/23/14516

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