The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives

The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives

Estrogens are steroid hormones with a wide range of biological activities. The excess of estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently causing intrahepatic cholestasis. Estrogen-induced cholestasis (EIC) may have increased incidence during pregnancy, and...

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Bibliographic Details
Main Authors: Yue Zu, Jinyu Yang, Chengliang Zhang, Dong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
estrogens
bile acid homeostasis
transporter
membrane fluidity
inflammation
intrahepatic cholestasis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.761255/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.761255/full

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