Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death

Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death

Abstract Background The ST6Gal-I sialyltransferase is upregulated in numerous cancers, and high expression of this enzyme correlates with poor patient prognosis in various malignancies, including ovarian cancer. Through its sialylation of a select cohort of cell surface receptors, ST6Gal-I modulates...

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Bibliographic Details
Main Authors: Colleen M. Britain, Andrew T. Holdbrooks, Joshua C. Anderson, Christopher D. Willey, Susan L. Bellis
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Ovarian Research
Subjects:
β-galactoside α2-6 sialyltransferase 1 (ST6GAL1)
Glycosylation
Epidermal growth factor receptor (EGFR) cell signaling
Gefitinib
Tumor cell biology
Kinomics
Online Access:http://link.springer.com/article/10.1186/s13048-018-0385-0

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http://link.springer.com/article/10.1186/s13048-018-0385-0

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