Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency

Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency

Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The isolates collected displayed distinct genomic and phenotypic features consistent with host adaptation and associated changes in antibiotic susce...

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Bibliographic Details
Main Authors: Cecilia B. Korol, Shamira J. Shallom, Kriti Arora, Helena I. Boshoff, Alexandra F. Freeman, Alejandra King, Sonia Agrawal, Sean C. Daugherty, Timothy Jancel, Juraj Kabat, Sundar Ganesan, Marina N. Torrero, Elizabeth P. Sampaio, Clifton Barry, Steve M Holland, Hervé Tettelin, Sergio D Rosenzweig, Adrian M. Zelazny
Format: Article
Language:English
Published: Taylor & Francis Group 2020-12-01
Series:Virulence
Subjects:
tuberculosis
bcg
antibiotic resistance
immunodeficiency
mendelian susceptibility to mycobacterial diseases
interferon-γ
Online Access:http://dx.doi.org/10.1080/21505594.2020.1848108

Internet

http://dx.doi.org/10.1080/21505594.2020.1848108

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