Boosted influenza-specific T cell responses after H5N1 pandemic live attenuated influenza virus (pLAIV) vaccination

Boosted influenza-specific T cell responses after H5N1 pandemic live attenuated influenza virus (pLAIV) vaccination

Background: In a phase I clinical trial, a H5N1 pandemic live attenuated influenza virus (pLAIV) VN2004 vaccine bearing avian influenza H5N1 HA and NA genes on the A/Ann Arbor cold-adapted vaccine backbone displayed very restricted replication. We evaluated T cell responses to H5N1 pLAIV vaccination...

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Bibliographic Details
Main Authors: Yanchun ePeng, Beibei eWang, Kawsar eTalaat, Ruth eKarron, Timothy J Powell, Hui eZeng, Danning eDong, Catherine J Luke, Andrew eMcMichael, Kanta eSubbarao, Tao eDong
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Immunology
Subjects:
T cells
Vaccine
influenza
peptide
H5N1
epitope
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00287/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00287/full

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