Assessment of genetic diversity of Plasmodium falciparum circumsporozoite protein in Sudan: the RTS,S leading malaria vaccine candidate

Assessment of genetic diversity of Plasmodium falciparum circumsporozoite protein in Sudan: the RTS,S leading malaria vaccine candidate

Abstract Background The currently used malaria vaccine, RTS,S, is designed based on the Plasmodium falciparum circumsporozoite protein (PfCSP). The pfcsp gene, besides having different polymorphic patterns, can vary between P. falciparum isolates due to geographical origin and host immune response....

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Bibliographic Details
Main Authors: Nouh Saad Mohamed, Hanadi AbdElbagi, Ahad R. Elsadig, Abdalla Elssir Ahmed, Yassir Osman Mohammed, Lubna Taj Elssir, Mohammed-Ahmed B. Elnour, Yousif Ali, Mohamed S. Ali, Omnia Altahir, Mustafa Abubakr, Emmanuel Edwar Siddig, Ayman Ahmed, Rihab Ali Omer
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum circumsporozoite protein (PfCSP)
Vaccine
RTS,S
Hapd
N-terminal, central repeats, and C-terminal regions
Online Access:https://doi.org/10.1186/s12936-021-03971-0

Internet

https://doi.org/10.1186/s12936-021-03971-0

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