Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R.

Host factors that microbial pathogens exploit for their propagation are potential targets for therapeuic countermeasures. No host enzyme has been identified whose genetic absence benefits the intact mammalian host in vivo during infection with Mycobacterium tuberculosis (Mtb), the leading cause of d...

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Bibliographic Details
Main Authors: Kangyun Wu, Jovanka Koo, Xiuju Jiang, Ran Chen, Stanley N Cohen, Carl Nathan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281035?pdf=render