Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment

Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment

ABSTRACTNew approaches for combating microbial infections are needed. One strategy for disrupting pathogenesis involves developing compounds that interfere with bacterial virulence. A critical molecular determinant of virulence for Gram-negative bacteria are efflux pumps of the resistance-nodulation...

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Bibliographic Details
Main Authors: Samual C. Allgood, Chih-Chia Su, Amy L. Crooks, Christian T. Meyer, Bojun Zhou, Meredith D. Betterton, Michael R. Barbachyn, Edward W. Yu, Corrella S. Detweiler
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
AcrAB-TolC
cryo-electron microscopy
Gram-negative bacteria
efflux pump
macrophage
SAFIRE
Online Access:https://journals.asm.org/doi/10.1128/mbio.02492-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02492-23

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