Biological Significance of Dual Mutations A494D and E495K of the Genotype III Newcastle Disease Virus Hemagglutinin-Neuraminidase In Vitro and In Vivo

Biological Significance of Dual Mutations A494D and E495K of the Genotype III Newcastle Disease Virus Hemagglutinin-Neuraminidase In Vitro and In Vivo

As a multifunctional protein, the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is involved in various biological functions. A velogenic genotype III NDV JS/7/05/Ch evolving from the mesogenic vaccine strain Mukteswar showed major amino acid (aa) mutations in the HN prote...

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Bibliographic Details
Main Authors: Xiaolong Lu, Tiansong Zhan, Kaituo Liu, Yu Chen, Zenglei Hu, Jiao Hu, Min Gu, Shunlin Hu, Xiaoquan Wang, Xiaowen Liu, Xiufan Liu
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
Newcastle disease virus
vaccine strain
genotype III
hemagglutinin-neuraminidase protein
biological significance
Online Access:https://www.mdpi.com/1999-4915/14/11/2338

Internet

https://www.mdpi.com/1999-4915/14/11/2338

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