Rasagiline Exerts Neuroprotection towards Oxygen–Glucose-Deprivation/Reoxygenation-Induced GAPDH-Mediated Cell Death by Activating Akt/Nrf2 Signaling

Rasagiline Exerts Neuroprotection towards Oxygen–Glucose-Deprivation/Reoxygenation-Induced GAPDH-Mediated Cell Death by Activating Akt/Nrf2 Signaling

Rasagiline (Azilect<sup>®</sup>) is a selective monoamine oxidase B (MAO-B) inhibitor that provides symptomatic benefits in Parkinson’s disease (PD) treatment and has been found to exert preclinical neuroprotective effects. Here, we investigated the neuroprotective signaling pathways of...

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Bibliographic Details
Main Authors: Shimon Lecht, Adi Lahiani, Michal Klazas, Majdi Saleem Naamneh, Limor Rubin, Jiayi Dong, Wenhua Zheng, Philip Lazarovici
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Biomedicines
Subjects:
akt
cell death
GAPDH
ischemia-like insult
neuroprotection
Nrf2
Online Access:https://www.mdpi.com/2227-9059/12/7/1592

Internet

https://www.mdpi.com/2227-9059/12/7/1592

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