Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease

Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades mRNAs with a premature stop codon, avoiding the synthesis of C-terminally truncated proteins. In addition to faulty mRNAs, NMD recognises ~10% of endogenous transcripts in human cells and downregulates their expres...

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Bibliographic Details
Main Authors: Lingling Sun, Justine Mailliot, Christiane Schaffitzel
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
nonsense-mediated mRNA decay
up-frameshift proteins
exon-junction complex
neurodevelopmental disease
cancer
viral NMD evasion
Online Access:https://www.mdpi.com/2227-9059/11/3/722

Internet

https://www.mdpi.com/2227-9059/11/3/722

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